Matrixyl Clinical Studies

The Sederma Corporation recently finished a series of trials on matrixyl, a new, science-based solution that offers great potential for skin restoration among mature adults. Matrixyl was designed to promote collagen and elastin production while strengthening the essential structural matrix of the skin tissue.

The research on matrixyl is extremely encouraging. A recent test lasted six months and involved a panel of 35 female volunteers with an average age of 58 years. It compared matrixyl to both a placebo (fake cream) and to 5% vitamin C. All three creams were applied twice daily.

The researchers discovered that matrixyl produced significantly different results than those obtained from the placebo or the product containing vitamin C. The results achieved with the matrixyl cream are as follows:

• Surface area of deep wrinkles reduced by an average of 68%
• Surface area of moderate wrinkles reduced by an average of 51%
• Density of furrows reduced by an average of 47%
• Volume of main wrinkles reduced by an average of 24%
• Roughness of the skin reduced by an average of 16%

The women in this study reported that matrixyl made their skin feel moisturized, smoother, and more supple and that it reduced wrinkles and lines.

These are very encouraging results, and matrixyl is showing signs as a first-line approach to nurturing mature skin and reducing the signs of aging.

Matrixyl®. Developed by French researchers, this patented blend supports the collagen/skin matrix and encourages the skin to produce new cells. The result: Researchers have shown up to a 90% reduction in the appearance of wrinkles, 76% improvement in suppleness and a full 92% moisturizing increase

Q: I've been reading a lot about an ingredient named Matrixyl, which is supposed to be a polypeptide that's good for aging skin. What is it, and does it have any value in skin care products?

A: Matrixyl is the registered trademark owned by Sederma, a French-based manufacturer of cosmetic active ingredients, and is an ingredient that includes the synthetic molecule palmitoyl pentapeptide-3-also known as Pal-KTTKS. Described by Sederma as a "messenger peptide" that is an effective alternative to vitamin C and retinol for "erasing" wrinkles, it is reported to stimulate skin fibroblasts, thereby inducing synthesis of a variety of components crucial for a youthful dermis. In vitro studies show it stimulates wrinkle-fighting collagen I by 117% percent, anti-sagging collagen IV by 357% and moisture-holding, dermal thickening glycosaminoglycans by 267%. The youth fostering effects of these actions was proven in a six-month, two-phase clinical study of 35 individuals, where a product containing Matrixyl was judged against a placebo cream and one with 5% pure vitamin C. The product with Matrixyl reduced the surface area of deep wrinkles by 68%, the density of furrows by an average of 46% and smoothed skin roughness by 16%. The vitamin C cream either made no improvement to the skin, or, in the case of wrinkle density, significantly worsened the situation.

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