Matrixyl is a lipopeptide that stimulates the matrix molecules in the skin, particularly collagen and fibronectin. Simply, it sends a chemical message to the cells to make new collagen.( Collagen is a protein - through the natural processes of aging, collagen in the skin is lost resulting in wrinkles) Matrixyl is a fatty acid mixed with amino acids. The active ingredient in Matrixyl is called Micro-collagen which is a peptide. When applied to the skin, Crème de la Crème Matrixyl penetrates the deeper layers of the skin. 

It is concluded from "Sederma", where our ingredient Matrixyl is produced, that after a wide range of tests carried out to study the cosmetic potential of the newly discovered protein fragment, Pal-KTTKS Micro-collagen, leads to remarkable results. Matrixyl with Micro-collagen contributes to the characteristics of a young, smoother less wrinkled skin.

 Make certain that Matrixyl is genuine from Sederma and not generic.   Also to be effective, you need to have 5-8% of Matrixyl.  Crème de la Crème Matrixyl has 10%.  Also added are Vitamins A (retinyl palmitate) Vitamin E, Allantoin, Green tea extract and complex Aeterna natural proteins.  Key ingredients are also Palmitoyl Oligopeptide ( which improves the resistance of the skin and builds up the moisture content - penetrates quickly) and Emblica.

Emblica, unlike the skin lightner, hydroquinone, has no side effects. Emblica has an exciting photoprotective property, which reduces  collagenase ( a protein that attacks the skin which is increased by UV light.) Emblica possesses powerful antioxidant properties which  increase skin hydration, reduce inflammation and help to preserve skin tone and integrity. It also lightens dark shadows and circles.

We did not include Argireline. Argireline based in Spain, works through an unique mechanism which relaxes facial tension with regular use leading to reduction of wrinkles.

Quoting  from Paula Begoun, who is the author of  "The Beauty Bible" she states, "Argireline is a  synthetically derived peptide  and has been shown to moderate excessive catecholamines release. I strongly doubt that any of that is true because there isn't a shred of research substantiating any part of it. However, even if it were vaguely true, that would not be good news for your body because you wouldn't want a cosmetic without any safety data, efficacy documentation, or independent research messing around with your catecholamines. 

" Catecholamines are compounds in the body that serve as neurotransmitters such as epinephrine, adrenaline, and dopamine. Epinephrine is a substance that prepares the body to handle emergencies such as cold, fatigue, and shock. A deficiency of dopamine in the brain is responsible for the symptoms of Parkinson's disease. None of that sounds like something you want a cosmetic to inhibit or reduce. What if you accidentally overuse the product or apply too much? It isn't known what excessive catecholamine release would mean for your body."
 

There is one more concern worth noting. Botox injections target specific muscles, whereas Argireline (if it indeed works) is likely to relax most of your face. And while Argireline may reduce wrinkles, it may also, in theory, increase facial sag because the neurotransmitters whose release Argireline inhibits, help maintain facial firmness. Therefore Argireline may prove to be a trade-off between wrinkle reduction and loss of facial firmness. In that light people prone to facial sag should approach it with caution.

Read the Article on Matrixyl that appeared in the Journal of Longevity. Written by Dr. Verretta Deorosan ( A graduate of UCLA School of Medicine Board Certified by the American Board of Internal Medicine.)

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